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ISC Publications

Publisher

medRxiv

Authors (6)

Brock A. Wester
Margaret C. Thompson
Francesco V. Tenore
Eric A. Pohlmeyer
Luke E. Osborn
Matthew S. Fifer
ISC Publications

2020

Intracortical Microstimulation Elicits Human Fingertip Sensations

Abstract

The restoration of cutaneous sensation to fingers and fingertips is critical to achieving dexterous prosthesis control for individuals with sensorimotor dysfunction. However, localized and reproducible fingertip sensations in humans have not been reported via intracortical microstimulation (ICMS) in humans. Here, we show that ICMS in a human participant was capable of eliciting percepts in 7 fingers spanning both hands, including 6 fingertip regions (i.e., 3 on each hand). Median percept size was estimated to include 1.40 finger or palmar segments (e.g., one segment being a fingertip or the section of upper palm below a finger). This was corroborated with a more sensitive manual marking technique where median percept size corresponded to roughly 120% of a fingertip segment. Percepts showed high intra-day consistency, including high performance (99%) on a blinded finger discrimination task. Across days, there was more variability in percepts, with 75.8% of trials containing the modal finger or palm region for the stimulated electrode. These results suggest that ICMS can enable the delivery of localized fingertip sensations during object manipulation by neuroprostheses.

Citation

article: Fifer2020.05.29.20117374 author: Fifer Matthew S and McMullen David P and Thomas Tessy M and Osborn Luke E and Nickl Robert W and Candrea Daniel N and Pohlmeyer Eric A and Thompson Margaret C and Anaya Manuel and Schellekens Wouter and Ramsey Nick F and Bensmaia Sliman J and Anderson William S and Wester Brock A and Crone Nathan E and Celnik Pablo A and Cantarero Gabriela L and Tenore Francesco V title: Intracortical Microstimulation Elicits Human Fingertip Sensations elocation-id: 2020.05.29.20117374 year: 2020 doi: 10.1101/2020.05.29.20117374 publisher: Cold Spring Harbor Laboratory Press abstract: The restoration of cutaneous sensation to fingers and fingertips is critical to achieving dexterous prosthesis control for individuals with sensorimotor dysfunction. However localized and reproducible fingertip sensations in humans have not been reported via intracortical microstimulation (ICMS) in humans. Here we show that ICMS in a human participant was capable of eliciting percepts in 7 fingers spanning both hands including 6 fingertip regions (i.e. 3 on each hand). Median percept size was estimated to include 1.40 finger or palmar segments (e.g. one segment being a fingertip or the section of upper palm below a finger). This was corroborated with a more sensitive manual marking technique where median percept size corresponded to roughly 120\% of a fingertip segment. Percepts showed high intra-day consistency including high performance (99\%) on a blinded finger discrimination task. Across days there was more variability in percepts with 75.8\% of trials containing the modal finger or palm region for the stimulated electrode. These results suggest that ICMS can enable the delivery of localized fingertip sensations during object manipulation by neuroprostheses.Competing Interest StatementThe authors have declared no competing interest.Clinical TrialNCT03161067Funding StatementThis research was developed with funding from the Defense Advanced Research Projects Agency\textquoterights (DARPA; Arlington VA) Revolutionizing Prosthetics program (contract number N66001-10-C-4056). Development of experimental setup and support for regulatory submissions associated with this study were provided by a grant from the Alfred E. Mann Foundation. Study software infrastructure and study preparation were developed with internal funding from Johns Hopkins University Applied Physics Laboratory and Johns Hopkins University. Author DeclarationsI confirm all relevant ethical guidelines have been followed and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:This study was conducted under Investigational Device Exemption (IDE 170010) by the Food and Drug Administration (FDA) for the purpose of evaluating bilateral sensory and motor capabilities of microelectrode array implants. The study protocol was approved by the FDA the Johns Hopkins Institutional Review Board (JH IRB) and NIWC Pacific IRB.All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively please provide a statement in the trial ID field explaining why the study was not registered in advance).Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files if applicable.YesData is not publicly available at this time. URL: https://www.medrxiv.org/content/early/2020/06/08/2020.05.29.20117374 eprint: https://www.medrxiv.org/content/early/2020/06/08/2020.05.29.20117374.full.pdf journal: medRxiv

Citation

article: Fifer2020.05.29.20117374 author: Fifer Matthew S and McMullen David P and Thomas Tessy M and Osborn Luke E and Nickl Robert W and Candrea Daniel N and Pohlmeyer Eric A and Thompson Margaret C and Anaya Manuel and Schellekens Wouter and Ramsey Nick F and Bensmaia Sliman J and Anderson William S and Wester Brock A and Crone Nathan E and Celnik Pablo A and Cantarero Gabriela L and Tenore Francesco V title: Intracortical Microstimulation Elicits Human Fingertip Sensations elocation-id: 2020.05.29.20117374 year: 2020 doi: 10.1101/2020.05.29.20117374 publisher: Cold Spring Harbor Laboratory Press abstract: The restoration of cutaneous sensation to fingers and fingertips is critical to achieving dexterous prosthesis control for individuals with sensorimotor dysfunction. However localized and reproducible fingertip sensations in humans have not been reported via intracortical microstimulation (ICMS) in humans. Here we show that ICMS in a human participant was capable of eliciting percepts in 7 fingers spanning both hands including 6 fingertip regions (i.e. 3 on each hand). Median percept size was estimated to include 1.40 finger or palmar segments (e.g. one segment being a fingertip or the section of upper palm below a finger). This was corroborated with a more sensitive manual marking technique where median percept size corresponded to roughly 120\% of a fingertip segment. Percepts showed high intra-day consistency including high performance (99\%) on a blinded finger discrimination task. Across days there was more variability in percepts with 75.8\% of trials containing the modal finger or palm region for the stimulated electrode. These results suggest that ICMS can enable the delivery of localized fingertip sensations during object manipulation by neuroprostheses.Competing Interest StatementThe authors have declared no competing interest.Clinical TrialNCT03161067Funding StatementThis research was developed with funding from the Defense Advanced Research Projects Agency\textquoterights (DARPA; Arlington VA) Revolutionizing Prosthetics program (contract number N66001-10-C-4056). Development of experimental setup and support for regulatory submissions associated with this study were provided by a grant from the Alfred E. Mann Foundation. Study software infrastructure and study preparation were developed with internal funding from Johns Hopkins University Applied Physics Laboratory and Johns Hopkins University. Author DeclarationsI confirm all relevant ethical guidelines have been followed and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:This study was conducted under Investigational Device Exemption (IDE 170010) by the Food and Drug Administration (FDA) for the purpose of evaluating bilateral sensory and motor capabilities of microelectrode array implants. The study protocol was approved by the FDA the Johns Hopkins Institutional Review Board (JH IRB) and NIWC Pacific IRB.All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively please provide a statement in the trial ID field explaining why the study was not registered in advance).Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files if applicable.YesData is not publicly available at this time. URL: https://www.medrxiv.org/content/early/2020/06/08/2020.05.29.20117374 eprint: https://www.medrxiv.org/content/early/2020/06/08/2020.05.29.20117374.full.pdf journal: medRxiv