Technologies


Electro-Optical Device for Monitoring Instantaneous Singlet Oxygen Concentration Produced During the Treatment of Cancer

Reference#: P00031


A method and apparatus are disclosed for optically monitoring the concentration of singlet oxygen produced during photoradiation. A composite optical emission in the 1.27 micron frequency band is detected and electrically processed to separate a first component due to the decay of singlet oxygen from a second unwanted component due to the fluorescence of the photosensitizing dye. A pulsed excitation source is used to excite the photosensitizing dye and a time domain signal processor, such as a box-car integrator, is used to separate and process the singlet oxygen emission component in the time domain. The magnitude and/or other characteristics of the singlet oxygen emission component can be used to determine properties of complex biological or other media. In a therapeutic environment the treating physician to set a therapeutic light dosimetry can use the magnitude and/or other characteristics of the singlet oxygen emission. Patent #4592361 A method and apparatus are disclosed for optically monitoring the concentration of singlet oxygen produced during photoradiation. A composite optical emission in the 1.27-micron frequency band is detected and electrically processed to separate a first component due to the decay of singlet oxygen from a second unwanted component due to the fluorescence of the photosensitizing dye. A chopped CW excitation source is used to excite the photosensitizing dye, and a signal-processing means such as a lock-in amplifier is used to separate the singlet oxygen emission component, which appears out of phase from the chopped excitation signal and the in-phase photosensitizer fluorescence. The magnitude and/or other characteristics of the singlet oxygen emission component can be used to determine properties of complex biological or other media. In a therapeutic environment the treating physician to set a therapeutic light dosimetry can use the magnitude and/or other characteristics of the singlet oxygen emission. Patent #4576173

CONTACT:
Mr. J. E. Dietz
Phone: (443) 778-8782
ott-techmanager5@jhuapl.edu

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Patent Drawing
Patent Drawing