
Biomedical/Biochemical
Applications |
| 1793 |
Diagnosis of Pathogen Infections Using Mass Spectral
Analysis of Immune System Modulators
A library containing mass spectral patterns
has been assembled from responses of the immune system to known
pathogens that are compared and matched with responses to unknown
infections, aiding in diagnosis.
|
1809 1826
1845
1849
1850 |
Methods and Devices for Detection and Diagnosis
of Malaria
Methods and Devices for Digital Microscopy Based Automated
Diagnosis of Blood-borne Parasites
Method to Accumulate and Increase the Concentration of Heme
in Test Samples for Transporting and Testing
Use of Laser Desorption (LD) and Matrix Assisted LD Ionization
Mass Spectrometry to Detect Fecal Blood
Direct Mass Spectroscopic Analysis of Blood Samples to Detect
Heme as an Indicator of Malaria Infection |
|
Researchers at
The Johns Hopkins University Applied Physics Laboratory
and The Bloomberg School of Public Health have developed
a complement of highly sensitive and specific procedures
for the rapid detection of heme in biological samples. Heme
is the deep red iron-containing part of hemoglobin and myoglobin.
In some disease states, heme may become disassociated from
red blood cells and can be mass spectrometrically or electrochemically
detected in blood, stool, cerebro-spinal fluid or urine
samples. Circumstances that cause the presentation of heme
include malarial or other blood-borne parasite infections,
colon cancer, internal bleeding, disease, trauma, and kidney
or urinary tract infections. Direct laser desorption time-of-flight
mass spectrometry, electrochemical sensors or optical recognition
algorithms are used individually or in conjunction with
each other to alleviate time-consuming direct inspection
by technicians. Early detection assists in successful treatments
and reduced medical fees.
|

Communications
and Distributed Systems |
| 1861 |
Remote Monitoring and Relaying Device for Audible
Alarms
A small electronic apparatus is worn
close to the ear, attached to eyeglasses, earrings or other
accessories around the same area. It selectively detects alarms
that the wearer cannot hear because of hearing impairments or
environmental noise. Watch alarms, cell phone chimes, PDA alerts
or any other electronic sounds are detected and relayed as louder,
more audible cues; however, ambient noises are not amplified.
The device functions without altering the user's commercial
devices.
|

Information Processing
and Management |
| 1825 |
Chebyshev Data Compression
The need for data reduction during space
missions led to this novel method of compression that enables
large quantities of scientific information to be moved between
remote spacecraft and Earth. The Chebyshev technique addresses
the limitations imposed by space missions, including finite
power resources, processing speed and available memory. This
ideal compression algorithm is implemented in real time to preserve
memory resources. It is fast and computationally simple, and
is able to prevent total data loss in the event of corruption
during transmission. The technique could be incorporated into
standard data compression techniques to optimize and enhance
commercial transmission of images, text, video, audio or facsimile.
|
| 1829 |
Software for Automated
Coding of Medical Records
This software automatically codes unstructured
medical records that are stored as text in Microsoft Access.
This unique technology requires none of the industry standards
for content, structure or vocabulary. The coded information
can be grouped with data from other sources and analyzed for
various properties and patterns such as those associated with
disease outbreaks, epidemics and bioterrorist events.

|

Space and Environmental
Physics |
| 1802 |
Time of Flight System on a Chip
(TOF Chip)
 |
A single, mixed analog-digital,
low-power, precise time interval measurement chip will be
a valuable enabling technology for next-generation small
spacecraft, particularly for spacecraft constellations. |
|
| 1844 |
Reusable Java Library
and Science Planning Tools
A library and science planning software
tool was developed to improve the reusability of library components
compiled for specific projects that generate and use complex
and voluminous amounts of data. Currently used to plan space
missions, this tool could be used for any analytical project.
The tool is implemented in Java language for deployment on any
platform over the Web.
|

PATENTS
|
| 6,363,527 |
Thermal
Control Apparatus for Body Armor; Matthew G. Bevan, Paul J. Biermann.
(02 Apr 02)
Analysis of fatality statistics compiled
by the FBI suggests that a large percentage of law enforcement
deaths could have been prevented if the officer had been wearing
a bulletproof vest. Despite this evidence, many still choose
not to wear soft body armor due to increased weight, poor fit
and heat build-up. In addition to adding bulk and weight, the
protective layers of a vest insulate the wearers and trap heat
and moisture near their bodies. This APL-developed apparatus
uses an array of materials that transfer heat and moisture away
from the body and the body armor, keeping the wearer cooler
and unencumbered by the weight of perspiration, while reducing
degradation to the ballistic properties of the vest. The system
can be added to existing vests or included in the design of
new ones.
|
| 6,411,095 |
Apparatus and Method
for Locating an Object; Daniel C. Chin, Rengaswamy Srinivasan,
Paul R. Zarriello. (25 Jun 02)
Digging, probing and drilling holes
in the ground are damaging, exhaustive and time-consuming methods
for locating buried objects for removal or maintenance, such
as plastic and metal land mines, chemical and biological storage
drums/containers and buried pipelines (metal, concrete, and
plastic). This patented invention easily, inexpensively, reliably
and accurately locates objects buried in soil or immersed in
liquid. Depending on the specific conditions of each search,
the depth and size of an object can be determined from the detection
of the magnetic field an object will emit in response to a weak
AC signal applied at the surface. The response fields are analyzed
with accurate, reliable software specifically developed and
tested for this application. Computer simulations and field
tests illustrate that this method and device are superior to
other remote sensing methods used for locating buried objects.
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© 2002 The Johns Hopkins University
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