BEGIN:VCALENDAR PRODID:-//Microsoft Corporation//Outlook 14.0 MIMEDIR//EN VERSION:2.0 METHOD:PUBLISH X-MS-OLK-FORCEINSPECTOROPEN:TRUE BEGIN:VTIMEZONE TZID:Eastern Standard Time BEGIN:STANDARD DTSTART:16011104T020000 RRULE:FREQ=YEARLY;BYDAY=1SU;BYMONTH=11 TZOFFSETFROM:-0400 TZOFFSETTO:-0500 END:STANDARD BEGIN:DAYLIGHT DTSTART:16010311T020000 RRULE:FREQ=YEARLY;BYDAY=2SU;BYMONTH=3 TZOFFSETFROM:-0500 TZOFFSETTO:-0400 END:DAYLIGHT END:VTIMEZONE BEGIN:VEVENT CLASS:PUBLIC CREATED:20150526T183630Z DESCRIPTION:JHU/APL Colloquium - www.jhuapl.edu/colloquium\n\nTOPIC: The N ovel Neurotechnologies: Simultaneous 3D all-optical imaging and activatio n of neurons in living brains\n\nSPEAKER: Rafael Yuste\, M.D. Ph.D.\, Neu rotechnology Center\, Columbia University\n\nThe function of neural circui ts is an emergent property that arises from the coordinated activity of la rge numbers of neurons. To capture this\, we proposed launching a large-sc ale\, international public effort\, the Brain Activity Map Project\, aimed at reconstructing the full record of neural activity across complete neur al circuits. This project was the origin of the White House's BRAIN initia tive. As our contribution to this initiative\, I will review our efforts d eveloping optical methods to perform two-photon imaging and photostimulati on of neuronal populations using spatial light modulators\, PSF engineerin g and a variety of optical\, optogenetic and optochemical sensors. These t echniques have single cell resolution and enable online experiments on pop ulations of neurons\, such as detecting spatiotemporal patterns of neurona l activity in primary visual cortex from awake behaving mice and optically interfering with them. These novel neurotechnologies could prove to be an invaluable step toward understanding fundamental and pathological brain p rocesses.\n\n\nRafael Yuste is Professor of Biological Sciences and Neuros cience at Columbia University. He was born in Madrid\, where he obtained h is MD at the Universidad Autónoma. After a brief period in Sydney Brenner 's laboratory in Cambridge\, UK\, he performed Ph.D. studies with Larry Ka tz in Torsten Wiesel’s laboratory at Rockefeller University and was a po stdoctoral student of David Tank at Bell Labs. In 1996 he joined the Depar tment of Biological Sciences at Columbia University\, where he is Full Pro efessor. In 2005 he became HHMI Investigator and co-director of the Kavli Institute for Brain Circuits and in 2014 Director of the Neurotechnology C enter at Columbia. Yuste is interested in the structure and function of co rtical circuits\, the biophysical properties of dendritic spines and the p athophysiology of cortical diseases such as epilepsy and schizophrenia. To study these questions\, Yuste has pioneered the development of imaging te chniques\, such as calcium imaging of neuronal circuits\, two-photon imagi ng of spines and circuits\, photostimulation using inorganic caged compoun ds\, two-photon optogenetics and holographic spatial light modulation micr oscopy. Yuste has obtained many awards for his work\, including New York C ity Mayor's\, the Society for Neuroscience's Young Investigator and the NI H Director Pioneer Awards. Finally\, he led the group of researchers who p roposed the Brain Activity Map Project\, recently sponsored by the White H ouse’s BRAIN initiative.\n\n DTEND;TZID="Eastern Standard Time":20150529T143000 DTSTAMP:20150526T183630Z DTSTART;TZID="Eastern Standard Time":20150529T133000 LAST-MODIFIED:20150526T183630Z LOCATION:Parsons Auditorium\, 1-S124 PRIORITY:5 SEQUENCE:0 SUMMARY;LANGUAGE=en-us:Colloquium - Rafael Yuste\, M.D. Ph.D. - Columbia Un iversity TRANSP:OPAQUE UID:040000008200E00074C5B7101A82E0080000000050D784F2E2B6CF01000000000000000 010000000F3666F241567FA47A2A5FAD002A2C9BD X-ALT-DESC;FMTTYPE=text/html:\n\n
\n\nJHU/APL Colloquium - www.jhuapl.edu/colloquium
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SPAN>The f unction of neural circuits is an emergent property that arises from the co ordinated activity of large numbers of neurons. To capture this\, we propo sed launching a large-scale\, international public effort\, the Brain Acti vity Map Project\, aimed at reconstructing the full record of neural activ ity across complete neural circuits. This project was the origin of the Wh ite House's BRAIN initiative. As our contribution to this initiative\, I w ill review our efforts developing optical methods to perform two-photon im aging and photostimulation of neuronal populations using spatial light mod ulators\, PSF engineering and a variety of optical\, optogenetic and optoc hemical sensors. These techniques have single cell resolution and enable o nline experiments on populations of neurons\, such as detecting spatiotemp oral patterns of neuronal activity in primary visual cortex from awake beh aving mice and optically interfering with them. These novel neurotechnolog ies could prove to be an invaluable step toward understanding fundamental and pathological brain processes.< SPAN LANG="en-us">
\nRafael Yuste is Professor of Biological Sciences and Neuroscience at Columbia U
niversity. He was born in Madrid\, where he obtained his MD at the Univers
idad Autónoma. After a brief period in Sydney Brenner's laboratory in Cam
bridge\, UK\, he performed Ph.D. studies with Larry Katz in Torsten Wiesel
’s laboratory at Rockefeller University and was a postdoctoral student o
f David Tank at Bell Labs. In 1996 he joined the Department of Biological
Sciences at Columbia University\, where he is Full Proefessor. In 2005 he
became HHMI Investigator and co-director of the Kavli Institute for Brain
Circuits and in 2014 Director of the Neurotechnology Center at Columbia. Y
uste is interested in the structure and function of cortical circuits\, th
e biophysical properties of dendritic spines and the pathophysiology of co
rtical diseases such as epilepsy and schizophrenia. To study these questio
ns\, Yuste has pioneered the development of imaging techniques\, such as c
alcium imaging of neuronal circuits\, two-photon imaging of spines and cir
cuits\, photostimulation using inorganic caged compounds\, two-photon opto
genetics and holographic spatial light modulation microscopy. Yuste has ob
tained many awards for his work\, including New York City Mayor's\, the So
ciety for Neuroscience's Young Investigator and the NIH Director Pioneer A
wards. Finally\, he led the group of researchers who proposed the Brain Ac
tivity Map Project\, recently sponsored by the White House’s BRAIN initi
ative.
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